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Optimizing pregnancy outcomes in patients with PCOS necessitates a multifaceted therapeutic approach centered on promoting follicular maturation, inducing ovulation, and enhancing endometrial receptivity

Among these, mesenchymal stem cells (MSCs) have become the most promising therapeutic tools due to their self-renewal, multilineage differentiation potential, low immunogenicity, and immunomodulatory properties (Ogaili et al., 2025)

updated November 2024

Callaway Jr

Despite the widespread use of levothyroxine replacement therapy, a substantial proportion of patients continue to experience persistent symptoms and metabolic dysregulation even after achieving biochemical euthyroidism

High levels of estrogen, especially that of estradiol, before the menopause may be involved in the high energy capacity as well as the control of redox balance in female brain (Figure 1)